Bee products, particularly honey (notably Manuka honey), propolis, and royal jelly, have been investigated for their potential role in supporting or treating acne. The scientific basis for their use is moderate and largely centers on their antimicrobial, anti-inflammatory, and wound-healing properties. Honey has been shown in several in vitro and small clinical studies to exert antibacterial action against Propionibacterium acnes (now called Cutibacterium acnes), the bacterium implicated in acne pathogenesis. Manuka honey, in particular, demonstrates strong activity due to its methylglyoxal content.

Propolis, a resinous bee product, contains flavonoids and phenolic acids with anti-inflammatory and antimicrobial effects. Some small studies and case reports suggest topical propolis may reduce acne lesion counts and inflammation, though robust clinical trials are sparse. Royal jelly also shows some anti-inflammatory activity in experimental models, but its direct application in acne is less well-studied.

Overall, while bee products have a long history of use for wound healing and skin care, the scientific evidence for their efficacy in acne is promising but not definitive. Most studies are small, non-randomized, or in vitro, so more high-quality clinical trials are needed to fully establish their role. Safety concerns include allergy risk, especially in individuals sensitive to bee products.