Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Epigallocatechin gallate (EGCG) is a major polyphenol found in green tea and has been studied for its potential benefits in managing acne. The scientific interest in EGCG for acne primarily stems from its anti-inflammatory, antioxidant, and antimicrobial properties, as well as its ability to modulate sebum production. Several in vitro and limited clinical studies suggest that EGCG can inhibit the growth of Cutibacterium acnes (formerly Propionibacterium acnes), a bacterium implicated in acne pathogenesis. Additionally, EGCG has been shown to reduce the expression of inflammatory cytokines and decrease sebum secretion by downregulating androgen receptor activity in sebocytes.

Some small clinical trials and topical application studies have indicated that EGCG-containing formulations may improve acne lesions and reduce sebum output, though the sample sizes are often small and methodologies variable. For example, a randomized controlled trial published in 2016 reported significant reductions in acne severity in subjects treated with a 2% EGCG cream compared to placebo. However, the overall clinical evidence is still preliminary and not yet robust enough to support widespread medical use, hence a moderate evidence rating of 2 out of 5. Larger, well-designed trials are needed to confirm its efficacy and establish standardized formulations and dosing. Despite these limitations, EGCG is increasingly included in acne care products due to its favorable safety profile and promising, albeit early, scientific data.

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Other ingredients used for Acne

Other health conditions supported by epigallocatechin gallate (EGCG)

Products containing epigallocatechin gallate (EGCG)

Metagenics Akkermansia Co.™ Healthy Weight with Glucose Control
Designs For Health EGCg
Metagenics Wellness Essentials Healthy Balance Daily Packs