Evidence supporting the use of: Estrogen
For the health condition: Acne

Links: Go back one page, Tool main page, Ingredients list, Health conditions list, Body systems list

Synopsis

Source of validity: Scientific
Rating (out of 5): 4

Estrogen is scientifically validated as a treatment for acne, particularly in females. The rationale is based on the hormone's ability to counteract androgens, which stimulate sebaceous (oil) gland activity and can cause or worsen acne. Combined oral contraceptives (COCs) containing both estrogen and a progestin are frequently prescribed for moderate to severe acne in women, especially when other treatments have failed or when hormonal imbalance is suspected. Clinical trials and systematic reviews have shown that COCs reduce acne lesion counts and severity by decreasing circulating androgens and increasing sex hormone-binding globulin, which lowers free testosterone levels. This hormonal modulation leads to reduced sebum production, a key factor in acne pathogenesis. Estrogen alone is less commonly used, but its inclusion in COCs is crucial for the anti-acne effect. The U.S. FDA has approved several COCs specifically for acne treatment. However, estrogen therapy is not used for acne in males due to undesirable feminizing effects. While effective, estrogen-containing therapies may pose side effects such as increased risk for thromboembolism, and are contraindicated in some populations. Overall, the use of estrogen for acne in women is well-supported by robust scientific evidence and clinical practice guidelines.

More about Estrogen
More about Acne

Products containing Estrogen

We currently have no products on Vitabase that contain this ingredient.