Evidence supporting the use of: Flavonoid
For the health condition: Acne

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Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Flavonoids are a diverse group of plant-derived polyphenolic compounds known for their antioxidant, anti-inflammatory, and antimicrobial properties. Scientific interest in their use for acne management arises from these biological activities, particularly their potential to modulate inflammatory pathways and reduce bacterial growth associated with acne lesions. Limited in vitro and animal studies have demonstrated that certain flavonoids (such as quercetin, epigallocatechin gallate from green tea, and others) can inhibit the growth of Cutibacterium acnes (formerly Propionibacterium acnes), the bacterium implicated in acne pathogenesis, and reduce inflammation by modulating cytokine production.

A small number of clinical studies have explored topical or oral preparations containing flavonoids in acne patients. For example, green tea extracts (rich in catechins, a subclass of flavonoids) have shown some benefit in reducing lesion counts and sebum production, though sample sizes are often small and methodologies variable. Systematic reviews generally conclude that while there is a biological rationale and some preliminary human data, robust large-scale clinical trials are lacking. Thus, the current scientific evidence supporting flavonoids for acne treatment is limited but promising, meriting a rating of 2/5.

Overall, flavonoids are not a traditional remedy for acne, but scientific exploration of their effects is ongoing, with early evidence indicating potential supportive roles, particularly as adjuncts to established therapies.

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