Evidence supporting the use of: Glycerol monolaureate
For the health condition: Acne

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Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Glycerol monolaureate (GML), also known as monolaurin, is a monoglyceride derived from lauric acid. Its use in acne is supported by some scientific evidence, though the overall strength of this evidence is limited and primarily preclinical. GML is known for its strong antimicrobial properties, especially against gram-positive bacteria such as Staphylococcus aureus and Propionibacterium acnes (recently renamed Cutibacterium acnes), which play a role in acne pathogenesis. In vitro studies have demonstrated that GML can inhibit the growth of these bacteria, suggesting a potential benefit in reducing the microbial component of acne.

Some laboratory research also indicates that GML may have anti-inflammatory effects, which could further contribute to its utility in acne management. However, there is a lack of robust clinical data—no large, high-quality human trials have specifically evaluated topical or oral GML for acne treatment. Most evidence remains at the laboratory or animal study level. GML's inclusion in some over-the-counter skincare products is based on these antimicrobial and anti-inflammatory properties, but its effectiveness in real-world acne treatment has not been firmly established.

In summary, while there is a scientific rationale and limited preliminary data supporting GML’s use for acne, clinical validation is lacking. The current evidence base justifies a modest rating of 2 out of 5 for its use in acne.

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