Evidence supporting the use of: Glycolic acid
For the health condition: Acne

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Synopsis

Source of validity: Scientific
Rating (out of 5): 4

Glycolic acid, an alpha-hydroxy acid (AHA) derived from sugar cane, is scientifically validated for use in the management of acne. Its primary mechanism involves exfoliation: glycolic acid breaks down the bonds between dead skin cells on the epidermis, promoting their shedding and reducing the risk of follicular plugging, a key factor in acne formation. Clinical studies have shown that glycolic acid, used in concentrations ranging from 5% to 70% (the latter typically in office-based chemical peels), can improve both inflammatory and non-inflammatory acne lesions. For instance, a randomized controlled trial published in the Journal of Dermatological Treatment (2006) demonstrated significant reduction in acne severity with 10% glycolic acid cream compared to placebo. Furthermore, glycolic acid may help fade post-inflammatory hyperpigmentation, which is a common sequela of acne, especially in individuals with darker skin types.

Professional guidelines, such as those published by the American Academy of Dermatology, recognize chemical exfoliants like glycolic acid as adjuncts in acne therapy, particularly for patients who do not tolerate retinoids or benzoyl peroxide. However, while the evidence is robust for its exfoliating and comedolytic effects, glycolic acid is rarely sufficient as monotherapy for moderate to severe acne and is more often used in combination with other treatments. Side effects are generally mild and include irritation and increased sensitivity to sunlight. Overall, glycolic acid is a scientifically validated, evidence-based option for supporting acne management.

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Products containing Glycolic acid

We currently have no products on Vitabase that contain this ingredient.