Evidence supporting the use of: Hydrogen peroxide
For the health condition: Acne

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Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Hydrogen peroxide has some scientific basis for use in the management of acne, but the evidence is limited and it is not considered a first-line or widely recommended treatment. Hydrogen peroxide is a strong oxidizing agent with antimicrobial properties, and it can kill bacteria on the skin, including Cutibacterium acnes, which is involved in the pathogenesis of acne. Some in vitro studies and case reports suggest that topical hydrogen peroxide (usually at low concentrations, such as 1% or 1.5%) may reduce acne lesions by decreasing bacterial load and helping resolve inflammation.

However, most clinical guidelines and dermatological reviews do not list hydrogen peroxide as a recommended treatment for acne. Instead, they favor agents with more robust evidence, such as benzoyl peroxide, retinoids, and antibiotics. Hydrogen peroxide can also be irritating to the skin, leading to dryness, redness, or even chemical burns, especially at higher concentrations. The US FDA has allowed some over-the-counter acne products containing hydrogen peroxide at low concentrations, but these are less common than those containing benzoyl peroxide.

Overall, while hydrogen peroxide does have a plausible mechanism and some supportive (but weak) evidence for acne management, its use is limited by both the strength of evidence and concerns about skin irritation. More rigorous clinical studies would be needed to clarify its role, if any, in standard acne therapy.

More about Hydrogen peroxide
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Products containing Hydrogen peroxide

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