Indian Fagonia (Fagonia indica) has a longstanding history of use in traditional medicine, particularly within Ayurveda and Unani systems. It is often employed as a remedy for various skin ailments, including acne. The rationale in traditional practice is based on its reputed "blood-purifying" properties and its ability to reduce inflammation and promote skin health. Texts and traditional healers describe its use in decoctions or topical pastes meant to soothe irritated skin and help clear up blemishes.

However, scientific research specifically evaluating Indian Fagonia for acne is limited. Some studies have demonstrated that Fagonia indica possesses general anti-inflammatory, antioxidant, and antimicrobial activities, which could theoretically support its use for inflammatory skin conditions like acne. Yet, these studies are mostly preliminary, conducted in vitro or in animal models, and do not provide direct clinical evidence for efficacy in human acne patients.

In summary, the use of Indian Fagonia for acne is primarily justified by traditional practices, with modest supporting evidence from laboratory studies on its anti-inflammatory and antimicrobial properties. Robust clinical trials in humans are lacking, so its use for acne remains underpinned more by historical precedent than by modern scientific validation.