Kigelia africana, also known as the sausage tree, has a long history of traditional use in African medicine for various skin ailments, including acne. Traditional healers have applied preparations made from the fruit, bark, or leaves to treat inflammatory skin conditions, wounds, and infections. The rationale for its use in acne stems from its reported antimicrobial and anti-inflammatory properties, which are thought to help reduce bacterial load and soothe inflamed skin.

Scientifically, some in vitro studies have demonstrated antimicrobial activity of Kigelia africana extracts against certain bacteria, including Staphylococcus aureus and Propionibacterium acnes, both of which are implicated in acne pathogenesis. Additionally, the plant contains compounds such as flavonoids, naphthoquinones, and iridoids, which may contribute to its anti-inflammatory and antioxidant activities. However, most of the evidence comes from laboratory studies rather than clinical trials in humans.

As of now, clinical data supporting the efficacy of Kigelia africana specifically for acne treatment are lacking. Its use for acne is therefore primarily justified by traditional practice, with some preliminary laboratory evidence suggesting possible benefits, but not enough to warrant strong scientific endorsement.