Evidence supporting the use of: Licorice
For the health condition: Acne

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Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Licorice (Glycyrrhiza glabra) has gained attention in dermatology, including for acne, due to its anti-inflammatory, antimicrobial, and antioxidant properties. The key component, glycyrrhizin, and other flavonoids in licorice extract have demonstrated the ability to inhibit pro-inflammatory mediators and suppress bacterial growth, including Propionibacterium acnes (now Cutibacterium acnes), which plays a role in acne pathogenesis.

Several in vitro studies and small clinical trials suggest that topical licorice extract can reduce redness, swelling, and bacterial load in acne-affected skin. For example, a 2014 randomized controlled trial found that a topical gel containing 2% licorice extract was as effective as 1% clindamycin gel in reducing mild to moderate acne lesions over four weeks. Licorice’s active compounds, such as glabridin and licochalcone A, are also known to suppress melanin synthesis, potentially helping with post-acne hyperpigmentation.

Despite promising preliminary data, the overall quality and quantity of clinical evidence remain limited. Most studies have small sample sizes, short durations, and variable formulations. No large-scale, long-term trials have established licorice as a primary or stand-alone acne treatment. Thus, while there is some scientific support for licorice’s role in acne management, the evidence is not robust and more research is needed before it can be considered a proven therapy.

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Products containing Licorice

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