Evidence supporting the use of: Mahonia (unspecified)
For the health condition: Acne

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Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Mahonia species, particularly Mahonia aquifolium (Oregon grape), have been investigated for their potential benefits in supporting or treating acne. The justification for their use is primarily scientific, though the overall quality and quantity of evidence is limited, so the rating is 2 out of 5. The main active compounds in Mahonia are alkaloids such as berberine, which have demonstrated antibacterial and anti-inflammatory properties in laboratory studies. Berberine, in particular, has been shown to inhibit the growth of Propionibacterium acnes (now Cutibacterium acnes), the bacterium associated with acne development, and to modulate inflammatory pathways involved in acne pathogenesis.

A few clinical trials and small studies have looked at topical Mahonia extracts in skin conditions, mainly psoriasis, but some formulations have been used in acne with reported benefit. For example, a 2012 randomized controlled trial indicated that a cream containing Mahonia aquifolium improved mild-to-moderate facial acne compared to placebo, though the study was small and not widely replicated. Additionally, the anti-inflammatory and antimicrobial activities of Mahonia extracts and berberine have been documented in vitro.

In summary, while there is some scientific basis for Mahonia’s use in acne due to its bioactive compounds, robust clinical evidence is lacking. More high-quality, large-scale human studies are necessary to confirm its efficacy and safety for acne. Its use is not primarily rooted in tradition but rather in recent pharmacological research.

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