Evidence supporting the use of: Mangostin
For the health condition: Acne

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Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Mangostin, a xanthone compound primarily found in the pericarp of the mangosteen fruit (Garcinia mangostana), has drawn scientific interest for its potential anti-acne properties. The scientific rationale is based on its demonstrated anti-inflammatory, antioxidant, and antimicrobial activities in vitro and in animal models. A handful of laboratory studies have shown that mangostin can inhibit the growth of Propionibacterium acnes (now Cutibacterium acnes), the bacteria associated with acne pathogenesis. Additionally, mangostin has been found to reduce the production of pro-inflammatory cytokines involved in the inflammatory response seen in acne lesions.

However, clinical evidence in humans is limited. Only a few small-scale studies and preliminary trials using topical formulations containing mangosteen extracts have reported modest improvements in acne lesions, but these studies often lack rigorous design, larger sample sizes, or direct investigation of mangostin as an isolated compound. The mechanism is plausible, but robust, high-quality clinical trials are lacking. As such, while there is a scientific basis for exploring mangostin as an anti-acne agent and some early supportive data, the overall evidence remains preliminary, and its use cannot yet be considered well validated for acne treatment.

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Products containing Mangostin

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