Nigella seed (Nigella sativa), also known as black seed or black cumin, has a long history of traditional use in various cultures for skin ailments, including acne. In recent years, some scientific studies have explored its potential benefits for acne management. The primary active compound in Nigella seed oil, thymoquinone, is known for its anti-inflammatory, antimicrobial, and antioxidant properties. These attributes are relevant to acne, which involves bacterial proliferation (notably Propionibacterium acnes), inflammation, and oxidative stress.

A handful of small clinical studies and laboratory investigations provide preliminary support for Nigella seed's use in acne. For example, a 2010 randomized controlled trial compared a topical 20% Nigella sativa ointment to benzoyl peroxide in mild-to-moderate acne and found comparable efficacy, with the Nigella group showing significant reductions in acne lesions and minimal side effects. In vitro studies have also demonstrated that Nigella seed oil can inhibit the growth of acne-causing bacteria and reduce inflammation.

However, the overall quality and quantity of clinical evidence remain limited. Most studies have small sample sizes, short durations, and lack replication. Thus, while the scientific rationale and early data are promising, larger and more rigorous trials are needed to fully validate Nigella seed’s efficacy and safety for acne.