Paederia foetida, commonly known as skunkvine, has a long history of use in traditional medicine across Southeast Asia and India. Traditionally, the leaves and other parts of the plant have been used for their purported anti-inflammatory, antimicrobial, and wound-healing properties. In the context of acne, ethnobotanical records and Ayurvedic sources mention the topical application of Paederia foetida paste or extracts to affected skin, with the intention of reducing inflammation and promoting skin healing.

However, direct scientific studies investigating the effects of Paederia foetida on acne specifically are limited. Some in vitro and animal studies have highlighted the plant’s broad spectrum of bioactive compounds, including iridoid glycosides, flavonoids, and essential oils, which may possess anti-inflammatory and antimicrobial effects. These actions, in theory, could be beneficial for acne, a condition driven by inflammation and bacterial proliferation. A few preliminary studies have demonstrated antibacterial activity against Propionibacterium acnes (now Cutibacterium acnes), which is associated with acne, but these findings are not robust or widespread.

In summary, the use of Paederia foetida for acne is primarily justified by traditional medicine practices, with some weak scientific rationale based on its known phytochemical properties. There is a lack of rigorous clinical evidence to support its efficacy or safety for acne treatment, and more research is needed to validate its traditional use.