Evidence supporting the use of: Terpinen-4-ol
For the health condition: Acne

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Synopsis

Source of validity: Scientific
Rating (out of 5): 3

Terpinen-4-ol and Acne: Scientific Evidence Overview

Terpinen-4-ol is a primary active component of tea tree oil (Melaleuca alternifolia) and is largely responsible for its antimicrobial and anti-inflammatory properties. Its use in acne treatment is supported by scientific studies, particularly those investigating tea tree oil formulations. Research indicates that terpinen-4-ol exhibits pronounced antibacterial activity against Cutibacterium acnes (formerly Propionibacterium acnes), a key bacterium involved in acne pathogenesis. In vitro studies confirm that terpinen-4-ol inhibits the growth of this bacterium and may reduce the inflammatory response associated with acne lesions.

Clinical evidence, while limited, includes several randomized controlled trials comparing tea tree oil gels (which contain terpinen-4-ol as the major active constituent) to placebo or standard treatments. These studies generally report reduced lesion counts and improved acne severity scores over periods of 6-12 weeks of topical application. However, the overall quality and size of these studies are moderate, and few have evaluated isolated terpinen-4-ol as opposed to whole tea tree oil.

In summary, the use of terpinen-4-ol for acne can be considered scientifically supported, with moderate-quality evidence (rating: 3/5) primarily from studies on tea tree oil, with further research needed to confirm efficacy and safety of terpinen-4-ol as an isolated compound.

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