Evidence supporting the use of: Thymoquinone
For the health condition: Acne

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Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Thymoquinone is a bioactive compound found in the seeds of Nigella sativa (black seed). There is emerging scientific interest in its potential to support the treatment of acne, primarily due to its demonstrated anti-inflammatory, antioxidant, and antimicrobial properties. Several in vitro studies have shown that thymoquinone can inhibit the growth of Propionibacterium acnes (now known as Cutibacterium acnes), the bacterium implicated in acne pathogenesis. Additionally, thymoquinone has been shown to suppress the production of pro-inflammatory cytokines and reduce oxidative stress in skin cells, both of which are relevant mechanisms in the development of acne lesions.

However, while these effects are promising, most of the evidence comes from laboratory and animal studies. Clinical research involving human subjects with acne is limited, with only a few small-scale studies or case reports evaluating topical formulations containing Nigella sativa or thymoquinone. These preliminary trials have noted some improvement in acne severity, but the studies are often limited by small sample sizes and lack of rigorous controls. Overall, while thymoquinone's use for acne has a plausible scientific basis and some supporting laboratory data, robust clinical evidence is lacking. Larger, well-designed clinical trials are needed to firmly establish its efficacy and safety for acne treatment.

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