Tinospora cordifolia, commonly known as Guduchi or Giloy, has a long-standing presence in traditional Ayurvedic medicine, where it is regarded as a "Rasayana" herb with general rejuvenating and immunomodulatory properties. Its use for acne specifically is rooted in its traditional application for various skin disorders, including pimples, boils, and chronic skin eruptions. Ayurvedic practitioners often recommend Tinospora cordifolia as part of herbal formulations aimed at "purifying the blood" and reducing "heat" or inflammation, which are believed to contribute to acne in traditional medicine systems.

Scientifically, Tinospora cordifolia has been shown to possess anti-inflammatory, antimicrobial, and antioxidant activities in preclinical studies. These properties could theoretically be beneficial for acne, which involves inflammation and sometimes bacterial overgrowth (notably Cutibacterium acnes). However, there is a lack of direct clinical studies or robust scientific evidence demonstrating the efficacy of Tinospora cordifolia specifically for the treatment of acne in humans. Most available data are either from in vitro experiments, animal studies, or broader investigations into its effects on skin health.

In summary, the use of Tinospora cordifolia for acne is primarily justified by traditional and historical usage patterns rather than strong scientific validation. The evidence is limited to traditional practice and indirect scientific rationale rather than high-quality clinical trials.