Evidence supporting the use of: Triterpenes
For the health condition: Acne

Links: Go back one page, Tool main page, Ingredients list, Health conditions list, Body systems list

Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Triterpenes are a class of natural compounds found in many plants, such as Centella asiatica (gotu kola), Ganoderma lucidum (reishi mushroom), and others. Some triterpenes, particularly asiaticoside, madecassoside, and betulinic acid, have demonstrated anti-inflammatory, antioxidant, and antimicrobial properties in laboratory studies. These properties are potentially relevant for acne, which involves inflammation and bacterial growth (primarily Cutibacterium acnes).

There is limited but growing scientific evidence suggesting that triterpenes may help support acne treatment. In vitro studies have shown that certain triterpenes can reduce inflammatory cytokine production and inhibit the growth of acne-associated bacteria. Some animal studies and early-phase clinical trials using topical formulations containing Centella asiatica extracts (rich in triterpenes) have reported reduced lesion counts and improvements in skin healing and inflammation. However, large, high-quality randomized controlled trials are lacking, and most evidence comes from small studies or studies of combination products.

In summary, the use of triterpenes for acne is supported by a modest scientific rationale and preliminary evidence, but robust clinical validation is lacking. The evidence rating is 2 out of 5, reflecting promising mechanisms and initial findings but insufficient high-level clinical data to strongly recommend their use specifically for acne treatment.

More about Triterpenes
More about Acne

Products containing Triterpenes

We currently have no products on Vitabase that contain this ingredient.