Evidence supporting the use of: Vitamin A (retinol)
For the health condition: Acne

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Synopsis

Source of validity: Scientific
Rating (out of 5): 4

Vitamin A, specifically in its retinoid forms (such as retinol, tretinoin, isotretinoin), is scientifically validated for the treatment of acne. Retinoids are derivatives of Vitamin A and have been a cornerstone of acne therapy for decades. Topical retinoids (like tretinoin, adapalene, and tazarotene) and oral isotretinoin are among the most effective treatments for moderate to severe acne. Their mechanisms of action include normalization of keratinization (preventing clogged pores), anti-inflammatory effects, and reduction of sebum production, all of which directly address the pathogenesis of acne. Multiple high-quality randomized controlled trials and meta-analyses support the efficacy of both topical and systemic retinoids in reducing both non-inflammatory and inflammatory acne lesions. Oral isotretinoin, in particular, is considered a definitive treatment for severe, recalcitrant acne and can induce long-term remission. However, high-dose Vitamin A supplements (as opposed to prescription retinoids) are not recommended due to the risk of toxicity and lack of evidence for comparable efficacy. The use of Vitamin A and its derivatives for acne is thus rooted in robust scientific evidence rather than mere tradition, though proper clinical supervision is necessary due to potential side effects, especially teratogenicity. The evidence rating of 4 reflects strong support from clinical research, with the caveat that not all forms of Vitamin A are equally effective for acne.

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