Evidence supporting the use of: Vitamin B3 (Niacinamide)
For the health condition: Acne

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Synopsis

Source of validity: Scientific
Rating (out of 5): 4

Niacinamide (Vitamin B3) is supported by scientific evidence for use in the treatment and support of acne. Several clinical studies have demonstrated that topical niacinamide can reduce inflammation, decrease sebum production, and improve the overall appearance of skin affected by acne vulgaris. For instance, a randomized trial published in 1995 by Shalita et al. found that a 4% niacinamide gel was comparable in efficacy to 1% clindamycin gel for treating mild to moderate inflammatory acne. Another study indicated that niacinamide has anti-inflammatory properties and can help reduce redness and lesion count. Additionally, niacinamide is known to strengthen the skin barrier and improve moisture retention, which can aid in skin healing and reduce irritation from other acne treatments.

Oral niacinamide has also been studied, but most evidence supports the topical application for acne. The mechanism of action includes inhibition of inflammatory cytokines, reduction in sebaceous gland activity, and antimicrobial effects. While niacinamide is not always the first-line treatment for acne, it is considered a well-tolerated, effective adjunct to other therapies, especially for patients who cannot tolerate retinoids or antibiotics. Overall, its use is grounded in scientific validation, with a moderate to strong level of evidence.

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