Evidence supporting the use of: Vitamin B3 (unspecified)
For the health condition: Acne

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Synopsis

Source of validity: Scientific
Rating (out of 5): 3

Vitamin B3, which includes niacin (nicotinic acid) and its amide form niacinamide (nicotinamide), is supported by scientific evidence for its use in the management of acne, particularly in its topical form. Several clinical studies have demonstrated that topical niacinamide can reduce inflammation, sebum production, and the overall severity of acne lesions. For example, randomized controlled trials have shown that a 4% topical niacinamide gel is comparable in efficacy to 1% clindamycin gel, a commonly prescribed topical antibiotic for acne. The proposed mechanisms include anti-inflammatory effects, improved skin barrier function, and reduction of excess oil production, all of which are relevant to acne pathogenesis.

However, it is important to note that the evidence primarily relates to topical niacinamide rather than oral niacin or niacinamide supplements. Oral Vitamin B3 has not been well-studied for acne and is not a standard treatment. Most research does not support the use of niacin (nicotinic acid) specifically, as opposed to niacinamide. Nonetheless, the topical use of niacinamide is endorsed by dermatological guidelines as an adjunct or alternative to antibiotics for mild to moderate acne, with a favorable safety profile. In summary, while the use of Vitamin B3 (specifically niacinamide) for acne is scientifically validated in topical formulations, evidence for oral use is lacking, and the overall strength of evidence is moderate.

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