Synopsis

Source of validity: Scientific
Rating (out of 5): 1

Vitamin B5 (calcium pantothenate) has been investigated as a treatment for acne, but the evidence supporting its efficacy is limited and preliminary. The interest in B5 for acne is based primarily on a few small-scale studies and case reports. One open-label pilot study published in 1995 by Dr. Lit-Hung Leung suggested that high doses of pantothenic acid (10g/day) reduced acne lesions, possibly by enhancing coenzyme A (CoA) production and thereby improving fatty acid metabolism in the skin. However, this study had significant methodological limitations, including lack of randomization, control, and blinding.

Subsequent research has been scant, with a few small, non-randomized, or non-blinded studies suggesting potential benefits, but no large-scale, high-quality randomized controlled trials have confirmed these findings. The proposed mechanism is theoretical: by increasing CoA availability, B5 may help regulate lipid metabolism in sebaceous glands, reducing sebum production, which is a contributing factor in acne. However, this mechanism has not been conclusively demonstrated in human studies.

Major dermatological guidelines and reviews do not recommend Vitamin B5 as a standard treatment for acne due to insufficient evidence. Overall, while there is some preliminary scientific interest, the evidence is weak (rating: 1/5), and Vitamin B5 should not be considered a validated or primary therapy for acne at this time.

More about Vitamin B5 (calcium pantothenate)
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Other ingredients used for Acne

Ajoene
Aloe vera
alpha-pinene
berberine
bisabolol
black cumin
burdock
bасора
cannabis sativa oil
chamomile
cucumber
turmeric
curcumin
DIM (diindolylmethane)
epigallocatechin gallate (EGCG)
evening primrose oil
garlic bulb
green tea
hemp oil
honeysuckle
L-cystine
lactobacillus acidophilus
lactobacillus casei
lactobacillus reuteri
lactobacillus rhamnosus
lactoperoxidase
lauric acid
lavender
licorice root
monolaurin
niacinamide (Vitamin B3)
omega-3 fatty acids
omega-6 fatty acids
oregon grape
pantothenic acid (vitamin B5)
phenolic compounds
scrophularia root
sphaeranthus indicus
thyme
tomato
vitamin A
vitamin B
vitamin C
vitamin D
vitamin E
seaweed
zinc
shen-chu
neem tree
paederia foetida
tinospora cordifolia
blackboard tree
chrysanthemum
morinda
oriental arborvitae
trace minerals
anemarrhena asphodeloides
fulvic acid
herbal blend (proprietary)
melaleuca alternifolia
indigo leaves
15,16-Dihydrotanshinone I
Ash
Apple Cider Vinegar
Alpha-terpineol
Azelaic acid
Allicin
Abrus
Andrographolide
Alpha Hydroxy Acids
Allantoin
Asteracea
Argan nut oil
Anemarrhena
Bee Propolis
Black Seed
Babchi
Baphicacanthus cusia
Bidens pilosa
Banyan
Bee products
Bassia scoparia
Coconut
Caryophyllene
Calendula
Chlorophyllin
Carvacrol
Curcuminoid
Chinese Raisintree
Curcumen
Centipeda
Curcuma
Chinatree
Castile Soap
Copaiba Oil
Clerodendrum indicum
Cannabichromene
Cannabigerol
Dianthus
Eclipta
Essential Oil Blend
Evening Primrose Oil
Ethyl Linoleate
Eugenol
Estrogen
Fatty acids
Gallic Acid
Glycolic acid
Glyceryl monolaurate
Glabridin
Honey
Heal-All
Hydrocolloid
Henna
Himalaya Berry
Hemp
Isatis
Immortelle
Indian Fagonia
Jojoba Oil
Kigelia africana
Kokilaksha
Lactobacillus plantarum
Litsea
Lactic Acid
Lactobacillus
Labdanum
Melia
Monoterpenes
Mangostin
Momordica
Mahonia
Marking Nut Tree
Nigella Seed
Propolis
Pentacyclic triterpenoids
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Peptides
Sophora
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Stellaria dichotoma
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Terpenoids
Thymoquinone
Terpinen-4-ol
Triterpenes
Thymol
Tea Tree Oil
Tagetes
Violet
Viola
White Tea
Wrightia tinctoria
Witch Hazel
Xanthorrhizol

Other health conditions supported by Vitamin B5 (calcium pantothenate)

Acne
Burning Feet or Hands
Canker Sores
Convalescence
Dermatitis
Hair (loss or thinning)
Stress
Wounds and Sores

Products containing Vitamin B5 (calcium pantothenate)

We currently have no products on Vitabase that contain this ingredient.