Evidence supporting the use of: Vitamin B5 (Pantothenic Acid)
For the health condition: Acne

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Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Vitamin B5 (Pantothenic Acid) has some emerging scientific evidence supporting its use in the management of acne, though the data is still limited and not yet considered robust. The interest in pantothenic acid for acne stems from its role in lipid metabolism and the synthesis of coenzyme A, which is involved in fatty acid metabolism that could influence sebum production in the skin—a factor in acne development. A few small studies and one randomized controlled trial have investigated the effects of high-dose pantothenic acid supplementation on acne severity. A notable 2014 randomized, double-blind, placebo-controlled study found that participants taking a proprietary pantothenic acid supplement experienced a significant reduction in total facial lesions compared to placebo over 12 weeks. However, the study size was small (n=41), and independent replication is lacking. Other evidence is largely anecdotal or based on open-label observations. There is no widespread traditional or historical use of vitamin B5 for acne, and major dermatological guidelines do not currently recommend pantothenic acid as a standard acne therapy. While the mechanism is plausible and initial results are promising, more and larger-scale trials are needed before strong recommendations can be made. Thus, while scientific interest exists, the overall quality and quantity of evidence remain low.

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