Evidence supporting the use of: Vitamin C (Ascorbate)
For the health condition: Acne

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Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Vitamin C (Ascorbate) is sometimes used as a supportive treatment for acne, with a moderate but not robust scientific rationale. Vitamin C is a potent antioxidant that can reduce oxidative stress in the skin and is involved in collagen synthesis and wound healing. Acne pathogenesis involves inflammation and sometimes post-inflammatory hyperpigmentation, processes in which Vitamin C could theoretically play a beneficial role. Some in vitro and small clinical studies have shown that topical Vitamin C can reduce inflammation, support skin repair, and help fade post-acne hyperpigmentation. There is limited evidence that it can directly reduce acne lesions themselves.

There are few well-designed, large-scale randomized controlled trials assessing the efficacy of oral or topical Vitamin C alone for acne. Most available studies examine Vitamin C in combination with other ingredients or as part of broader skincare regimens. Topical Vitamin C is more commonly investigated, with some evidence suggesting it can aid in reducing redness and promoting healing after acne lesions resolve, rather than treating active breakouts. Oral Vitamin C supplementation does not have strong evidence for direct acne improvement in otherwise healthy individuals.

In summary, while there is some scientific rationale and preliminary evidence for the supportive use of Vitamin C in acne management—primarily for its anti-inflammatory and skin-repair properties—the direct evidence for significant improvement in acne lesions is limited. Thus, the scientific evidence supporting Vitamin C as a primary treatment for acne is weak to moderate (rated 2/5).

More about Vitamin C (Ascorbate)
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Products containing Vitamin C (Ascorbate)

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