Evidence supporting the use of: Gluthathione
For the health condition: Acquired Immune Deficiency Syndrome

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Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Glutathione is an endogenous antioxidant that plays a key role in cellular protection against oxidative stress. In the context of Acquired Immune Deficiency Syndrome (AIDS), scientific interest in glutathione arises from observations that individuals with HIV/AIDS often exhibit decreased levels of glutathione in plasma and immune cells. Oxidative stress is recognized as a contributor to HIV pathogenesis, including immune cell dysfunction and increased viral replication. Several in vitro and small human studies have demonstrated that glutathione supplementation or precursors (like N-acetylcysteine) can help restore glutathione levels and may improve certain immune parameters in HIV-positive individuals. Some research indicates that raising glutathione levels can decrease HIV replication in cultured cells and potentially improve lymphocyte function. However, clinical trials evaluating the direct impact of glutathione supplementation on disease progression, morbidity, or mortality in AIDS patients remain limited and have shown mixed or inconclusive results.

Overall, while there is a scientific rationale and some preliminary evidence supporting the use of glutathione as an adjunctive therapy in AIDS, the current clinical evidence is insufficient to warrant strong recommendations. Most guidelines do not endorse glutathione supplementation as standard care for HIV/AIDS due to the lack of large, well-designed clinical trials demonstrating clear clinical benefits.

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