Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Lactoferrin, a glycoprotein found in milk and other secretory fluids, has been investigated for its potential role in supporting individuals with Acquired Immune Deficiency Syndrome (AIDS). The interest in lactoferrin arises from its documented antiviral, antimicrobial, and immunomodulatory properties. In vitro studies have shown that lactoferrin can inhibit HIV replication by binding to viral particles or host cell receptors, thereby blocking virus entry into target cells. Several animal studies have also demonstrated a reduction in viral load and delayed disease progression with lactoferrin supplementation. However, the translation of these findings to clinical efficacy in human patients remains limited. A handful of small-scale clinical trials and observational studies have explored the use of lactoferrin as a supplementary therapy in HIV/AIDS patients. Some of these studies report modest improvements in immune parameters, such as increased CD4+ T cell counts and reduced opportunistic infections. Nevertheless, these studies are often limited by small sample sizes, short durations, and lack of rigorous controls. Systematic reviews and meta-analyses to date do not provide robust evidence to support lactoferrin as a standard treatment for AIDS. In summary, while there is a scientific rationale and some preliminary evidence supporting the adjunctive use of lactoferrin in HIV/AIDS, the overall quality and quantity of clinical data is insufficient. More large-scale, well-designed clinical trials are needed to determine its true efficacy and safety in this population.

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Metagenics Probioplex® Intensive Care Powder