Evidence supporting the use of: Protease Inhibitors
For the health condition: Acquired Immune Deficiency Syndrome

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Synopsis

Source of validity: Scientific
Rating (out of 5): 5

Protease inhibitors are a class of antiretroviral drugs that have strong scientific validation for use in the treatment of Acquired Immune Deficiency Syndrome (AIDS), which is caused by infection with the Human Immunodeficiency Virus (HIV). Their use is based on well-established scientific evidence from both laboratory and clinical studies. Protease inhibitors work by blocking the activity of the HIV-1 protease enzyme, which is essential for the maturation of infectious viral particles. By inhibiting this enzyme, these drugs prevent the virus from producing mature, functional copies of itself, thereby reducing viral load in the patient.

Since their introduction in the mid-1990s, protease inhibitors have been a cornerstone of Highly Active Antiretroviral Therapy (HAART), leading to dramatic reductions in AIDS-related morbidity and mortality. Numerous randomized controlled trials and long-term cohort studies have demonstrated that regimens containing protease inhibitors can significantly prolong life, restore immune function, and decrease the incidence of opportunistic infections in people living with HIV/AIDS. The use of protease inhibitors is endorsed by major health organizations, including the World Health Organization (WHO) and the U.S. Department of Health and Human Services (DHHS), as a part of standard antiretroviral therapy for HIV/AIDS. While resistance and side effects remain concerns, the efficacy and impact of protease inhibitors in AIDS treatment are well supported by high-quality clinical evidence.

More about Protease Inhibitors
More about Acquired Immune Deficiency Syndrome

Other health conditions supported by Protease Inhibitors

Acquired Immune Deficiency Syndrome
Hepatitis
Infection (viral)

Products containing Protease Inhibitors

We currently have no products on Vitabase that contain this ingredient.