Evidence supporting the use of: Cannabinoids
For the health condition: Addictions (drugs)

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Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Cannabinoids, particularly cannabidiol (CBD), have been investigated for their potential role in treating substance use disorders, including opioid, tobacco, and cannabis addiction. Preclinical studies suggest that cannabinoids may modulate the brain's reward pathways, reduce cravings, and alleviate withdrawal symptoms. Some small clinical trials and observational studies indicate that CBD may reduce cue-induced craving and anxiety in individuals with heroin use disorder and may help with tobacco cessation efforts. However, these studies are preliminary, often with small sample sizes and short follow-up periods, and results are mixed. There is also interest in using cannabinoids as a harm reduction approach, especially for individuals with cannabis dependence, where substitution with less potent or non-psychoactive cannabinoids like CBD might reduce problematic use.

Despite promising early findings, systematic reviews and major health organizations, such as the National Academies of Sciences, Engineering, and Medicine, conclude that current evidence is insufficient to firmly establish cannabinoids as effective treatments for addiction. Ongoing research, including larger and longer-term randomized controlled trials, is needed to clarify their efficacy and safety profile. Therefore, while there is emerging scientific rationale and some supporting evidence, the overall quality and quantity of data justify a relatively low evidence rating at this time.

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