Evidence supporting the use of: Kratom
For the health condition: Addictions (drugs)

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Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Kratom (Mitragyna speciosa) has gained attention for its use in supporting or treating addictions, particularly opioid addiction. The plant has a long history of traditional use in Southeast Asia as a stimulant and pain reliever, but its use in addiction is more recent and largely anecdotal. Scientifically, kratom contains alkaloids such as mitragynine and 7-hydroxymitragynine, which act on opioid receptors in the brain, producing analgesic and euphoric effects similar to opioids but with reportedly less severe withdrawal symptoms and lower risk of respiratory depression.

Some small human surveys and animal studies suggest that kratom may help reduce opioid withdrawal symptoms and cravings. For example, users in the United States have reported using kratom as a substitute for opioids or to manage withdrawal. However, rigorous clinical trials are lacking, and much of the available evidence comes from self-report surveys, case studies, and preclinical research. The U.S. National Institute on Drug Abuse (NIDA) acknowledges kratom’s opioid-like actions, but also warns of potential risks, including dependence, withdrawal, and toxicity.

Overall, while there is a plausible mechanism and some early evidence supporting kratom’s use in addiction, the quality of the evidence is low, and safety concerns remain unresolved. Regulatory agencies have not approved kratom for addiction treatment, and more controlled clinical trials are needed to determine its efficacy and safety.

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Products containing Kratom

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