Evidence supporting the use of: Nicotine
For the health condition: Addictions (drugs)
Synopsis
Source of validity: Scientific
Rating (out of 5): 4
Nicotine is primarily used as a pharmacological aid in the treatment of tobacco dependence and addiction. The scientific rationale is based on the principle of nicotine replacement therapy (NRT), which provides controlled doses of nicotine to individuals attempting to quit smoking or using tobacco products. This approach reduces withdrawal symptoms and cravings, facilitating smoking cessation while avoiding exposure to the harmful substances present in tobacco smoke. Multiple randomized controlled trials and meta-analyses have demonstrated the efficacy of NRT—delivered via patches, gum, lozenges, inhalers, or nasal sprays—in increasing quit rates compared to placebo or no treatment. The use of nicotine in this context is supported by guidelines from major health organizations, including the World Health Organization (WHO) and the Centers for Disease Control and Prevention (CDC).
There is, however, limited evidence for the use of nicotine to treat other forms of substance addiction (such as opioids, alcohol, or stimulants). Most research and clinical use are focused on nicotine addiction itself. In summary, the use of nicotine to support addiction treatment is scientifically validated, but primarily for tobacco dependence, with a robust evidence base justifying its use in this context.
Other health conditions supported by Nicotine
Addictions (drugs)Addictions (tobacco smoking or chewing)
Attention Deficit Disorder
Memory and Brain Function
Parkinson's Disease
Schizophrenia