Evidence supporting the use of: Oxytocin
For the health condition: Addictions (drugs)

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Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Oxytocin, a neuropeptide hormone known for its role in social bonding and childbirth, has been investigated for its potential in treating substance use disorders, including addiction to drugs such as cocaine, alcohol, and opioids. Preclinical studies in animals have shown that oxytocin administration can reduce drug-seeking behaviors, decrease withdrawal symptoms, and attenuate the rewarding effects of various substances. The hypothesized mechanisms include modulation of the brain's reward circuitry and enhancement of social behaviors that may buffer against addiction.

In humans, evidence is limited but growing. Some small clinical trials and pilot studies suggest oxytocin may reduce cravings and stress reactivity in people with substance use disorders. For instance, intranasal oxytocin has been found to decrease alcohol craving and improve social cognition in certain populations. However, results are inconsistent, and many studies have small sample sizes or methodological limitations. Systematic reviews and meta-analyses generally conclude that while preclinical evidence is promising, robust clinical data are lacking to support widespread use of oxytocin as a treatment for addiction.

Overall, the use of oxytocin for addiction is based on scientific investigation, primarily in animal models, with emerging but not yet conclusive evidence in humans. Its use should be considered experimental until larger, well-controlled clinical trials establish efficacy and safety.

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Products containing Oxytocin

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