Evidence supporting the use of: Puerain
For the health condition: Addictions (drugs)

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Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Puerarin, an isoflavone extracted from the root of the kudzu plant (Pueraria lobata), has been traditionally used in Chinese medicine, but in the context of addiction, its use is primarily supported by modern scientific studies rather than historical tradition. Research, particularly preclinical studies, has demonstrated that puerarin and kudzu extracts may reduce alcohol intake and drug-seeking behaviors in animal models. Several small-scale human clinical trials and pilot studies have explored kudzu extract's effect in reducing alcohol consumption, with some reporting a decrease in the number of drinks consumed and the rate of drinking in heavy drinkers. The proposed mechanism involves modulation of neurotransmitter systems such as dopamine and serotonin, as well as effects on alcohol metabolism.

However, the overall quality of evidence remains moderate to low due to small sample sizes, short durations, and methodological limitations. There are few well-powered, large-scale randomized controlled trials in humans, and data on its efficacy in treating addictions beyond alcohol (e.g., opioids, stimulants) are sparse and mostly limited to animal studies. Therefore, while there is some scientific validation for the use of puerarin/kudzu extract in supporting the treatment of addictions—especially alcohol—the evidence is not robust, and its use should be considered experimental pending further research.

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