Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Kudzu (Pueraria lobata) has a long history of use in traditional Chinese medicine, but its application for addiction—particularly alcohol dependence—has some degree of scientific investigation. A number of preclinical studies and small clinical trials have examined kudzu root extract and its isoflavones (notably puerarin, daidzin, and daidzein) for their potential to reduce alcohol intake. Research published as early as the 1990s suggested that kudzu components could decrease voluntary alcohol consumption in animal models. Small human trials, such as a 2005 study in Alcoholism: Clinical and Experimental Research, found that individuals given kudzu extract drank less alcohol when given free access in a laboratory setting compared to placebo. The mechanisms are not fully understood, but may involve alterations in alcohol metabolism or neurotransmitter pathways (e.g., dopamine, serotonin). However, these studies have generally been short-term, with small sample sizes, and inconsistent dosing regimens. There is limited evidence for kudzu’s efficacy in supporting the treatment of addictions other than alcohol (e.g., nicotine or other substances). Larger, well-controlled clinical trials are needed to establish both efficacy and safety for addiction treatment. Thus, while there is some scientific support, the quality and quantity of evidence are limited, justifying a moderate-low evidence rating.

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