Evidence supporting the use of: Tetrahydropalmatine
For the health condition: Addictions (general remedies for)

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Synopsis

Source of validity: Traditional
Rating (out of 5): 2

Tetrahydropalmatine (THP) is an alkaloid extracted from several plants, most notably Corydalis yanhusuo, which has a long history of use in traditional Chinese medicine (TCM). In TCM, Corydalis yanhusuo preparations have been used for centuries to address pain and various neurological complaints, and more recently, THP has been explored as a remedy for symptoms associated with substance withdrawal and addiction. The traditional use is mainly based on THP's sedative, anxiolytic, and analgesic effects, which are thought to alleviate withdrawal discomfort and cravings. Scientific research investigating THP's efficacy in treating addiction is limited but growing. Some animal studies suggest that THP may modulate dopaminergic pathways involved in the brain's reward system, potentially reducing drug-seeking behavior and withdrawal symptoms. A few small-scale clinical studies from China have reported that THP may help reduce opioid withdrawal symptoms and cravings, but these studies are generally limited by small sample sizes, lack of blinding, and methodological concerns. Overall, while there is a strong traditional basis for using THP in addiction support, scientific validation remains preliminary and inconclusive. More rigorous, large-scale clinical trials are needed to confirm its safety and efficacy for this purpose.

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