Evidence supporting the use of: 5-Hydroxytryptophan (5-HTP)
For the health condition: Addictions (sugar or refined carbohydrates)

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Synopsis

Source of validity: Scientific
Rating (out of 5): 2

5-HTP (5-hydroxytryptophan) is a naturally occurring amino acid and chemical precursor to serotonin. Its use in supporting or treating addictions, particularly to sugar or refined carbohydrates, is primarily based on its role in serotonin synthesis. Scientific studies have observed that low serotonin levels may contribute to cravings for carbohydrates and sugar, as carbohydrate intake may transiently increase brain serotonin and thus improve mood. Supplementing with 5-HTP is theorized to support serotonin production, potentially reducing these cravings. A handful of small clinical trials and animal studies have explored this application. For example, a double-blind study published in the "American Journal of Clinical Nutrition" (Cangiano et al., 1992) found that obese female subjects given 5-HTP consumed less carbohydrate and reported reduced appetite. Another study (Cangiano et al., 1998) showed that 5-HTP supplementation led to reduced caloric intake, particularly from carbohydrates, in overweight individuals. However, these studies are limited in size, and their populations may not represent all individuals with sugar or refined carbohydrate addiction. Systematic reviews note that, while 5-HTP shows promise in reducing food intake and carbohydrate cravings, the overall quality and quantity of evidence is limited. There is no robust clinical evidence directly supporting its use for addiction treatment beyond appetite and craving reduction. Larger, well-designed studies are needed to confirm efficacy and safety. In summary, there is preliminary scientific support for 5-HTP in reducing cravings for sugar and refined carbohydrates, but the evidence is modest and not definitive.

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