Evidence supporting the use of: L-tryptophan
For the health condition: Addictions (sugar or refined carbohydrates)

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Synopsis

Source of validity: Scientific
Rating (out of 5): 2

L-tryptophan, an essential amino acid, is a precursor to serotonin, a neurotransmitter involved in mood regulation, appetite, and impulse control. The theoretical basis for using L-tryptophan to support or treat addictions to sugar or refined carbohydrates comes from the observation that low serotonin levels may contribute to cravings for carbohydrate-rich foods, as carbohydrate intake can increase serotonin synthesis in the brain. Some small-scale studies and animal research suggest that L-tryptophan supplementation may reduce carbohydrate cravings and binge eating, potentially by boosting serotonin production and improving mood or satiety. For example, early clinical research in the 1980s and 1990s found that L-tryptophan supplementation could reduce carbohydrate intake in individuals with carbohydrate cravings or bulimia. However, the overall scientific evidence is limited and somewhat inconsistent. Larger, more rigorous clinical trials are lacking, and most studies have small sample sizes or methodological issues. The evidence is stronger for tryptophan’s role in mood disorders rather than specifically for sugar or refined carbohydrate addiction. Nevertheless, the biological rationale and some preliminary data provide modest scientific justification for its use in this context, though it should not be considered a primary or standalone treatment for addiction. Anyone considering tryptophan supplementation should consult with a healthcare provider due to potential side effects and interactions.

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