Evidence supporting the use of: Cortisol
For the health condition: Addison's Disease

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Synopsis

Source of validity: Scientific
Rating (out of 5): 5

Cortisol is scientifically validated as a treatment for Addison's Disease. Addison’s Disease, also known as primary adrenal insufficiency, is characterized by the inadequate production of cortisol (and often aldosterone) by the adrenal glands. Cortisol is an essential glucocorticoid hormone involved in metabolism, immune response, and stress adaptation. In patients with Addison’s Disease, endogenous production is insufficient due to destruction or dysfunction of the adrenal cortex.

The cornerstone of Addison’s Disease management is hormone replacement therapy, specifically with glucocorticoids such as hydrocortisone (the pharmaceutical form of cortisol), prednisone, or dexamethasone. Numerous clinical guidelines, including those from the Endocrine Society and other international endocrine organizations, recommend glucocorticoid replacement as the standard of care. Without appropriate cortisol replacement, patients are at risk of life-threatening adrenal crises.

The scientific evidence supporting cortisol’s use is robust, originating from a clear understanding of the pathophysiology of Addison’s Disease and decades of clinical experience. Clinical trials and observational studies have consistently demonstrated that cortisol replacement prevents symptoms such as fatigue, hypotension, and electrolyte imbalances, and significantly reduces morbidity and mortality. Thus, cortisol use in Addison's Disease is supported by strong scientific evidence and is considered essential therapy.

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