Evidence supporting the use of: Salt
For the health condition: Addison's Disease

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Synopsis

Source of validity: Scientific
Rating (out of 5): 5

Salt (sodium chloride) supplementation is scientifically validated in the management of Addison’s Disease. Addison’s Disease, or primary adrenal insufficiency, is characterized by deficient production of aldosterone and cortisol from the adrenal cortex. Aldosterone normally promotes sodium retention in the kidneys; its deficiency results in excessive sodium loss, dehydration, hypotension, and, if untreated, potentially life-threatening complications. Clinical guidelines, including those from the Endocrine Society and other endocrinology authorities, recommend increased dietary salt intake or salt supplementation for patients with Addison’s Disease, especially in hot climates, during exercise, or when experiencing gastrointestinal losses.

Scientific studies and decades of clinical experience have demonstrated that sodium supplementation helps prevent hyponatremia (low sodium levels), supports blood pressure, and reduces symptoms of salt wasting in Addison’s Disease. This practice is part of standard therapy, alongside glucocorticoid and mineralocorticoid (such as fludrocortisone) replacement. The need for salt supplementation may vary based on individual patient factors and the adequacy of mineralocorticoid replacement. In summary, there is strong scientific evidence for the use of salt to support patients with Addison’s Disease, making it an essential component of treatment protocols.

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