Evidence supporting the use of: Bovine (unspecified)
For the body system: Adrenal Cortex

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Synopsis

Source of validity: Traditional
Rating (out of 5): 1

Bovine (unspecified) adrenal extracts have a long history of use in traditional and alternative medicine, particularly in products targeting “adrenal support” or “adrenal fatigue.” The rationale behind their use is based on the concept of “like supports like,” where consuming animal adrenal tissue is believed to support human adrenal function. This idea traces back to early 20th-century organotherapy, when animal gland extracts were commonly used to address endocrine issues before the advent of purified hormone replacements (like hydrocortisone). However, the scientific evidence supporting the use of bovine adrenal extracts for adrenal cortex support in humans is minimal. Modern medical practice does not endorse the use of whole gland extracts, as there is no robust clinical data demonstrating efficacy or safety. Most current practices rely on synthetic or bioidentical hormones for adrenal insufficiency. Additionally, the adrenal cortex’s hormonal products (such as cortisol) are destroyed during digestion, rendering oral supplementation of glandular tissue largely ineffective at delivering active hormones. While some animal studies or anecdotal reports exist, there have been no well-controlled human trials confirming that bovine adrenal extracts provide any meaningful benefit to adrenal health. Regulatory agencies, such as the FDA, have also raised concerns about the safety and consistency of such supplements. In summary, the use of bovine adrenal extracts for adrenal cortex support is primarily based on traditional practices, with little scientific validation.

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