Bupleurum falcatum is a key herb in traditional Chinese medicine (TCM), where it is commonly known as Chai Hu. Historically, it has been used for over two millennia, primarily to "harmonize" and support liver function, treat fevers, and address various inflammatory conditions. In the context of the "adrenal cortex body system," its use is indirectly inferred: TCM theory links the adrenal glands with the kidney and liver energetic systems, and Bupleurum is often included in formulas intended to restore balance after chronic stress and fatigue, concepts that are sometimes mapped onto adrenal health in Western herbal practice.

However, direct scientific evidence connecting Bupleurum falcatum specifically to adrenal cortex support is limited. While some animal studies and in vitro experiments suggest that Bupleurum extracts (notably saikosaponins) may have anti-inflammatory and immunomodulatory effects, research on direct adrenal gland modulation is sparse and largely inconclusive. No robust clinical trials demonstrate Bupleurum's efficacy in treating "adrenal fatigue" or supporting adrenal hormone production in humans.

Overall, the use of Bupleurum falcatum for adrenal cortex support is based primarily on traditional herbal theory and indirect associations, rather than clear scientific validation targeting the adrenal cortex itself.