Evidence supporting the use of: DHEA
For the body system: Adrenal Cortex

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Table of Contents

Synopsis

Source of validity: Scientific
Rating (out of 5): 3

DHEA (dehydroepiandrosterone) is an endogenous steroid hormone produced primarily by the adrenal cortex. It serves as a precursor to both androgens and estrogens, and its levels naturally decline with age. DHEA supplementation has been investigated in the context of adrenal insufficiency, aging, and various other conditions. Scientific studies have shown that DHEA levels are often low in individuals with adrenal insufficiency or Addison's disease, and supplementation can restore serum DHEA to normal ranges. Some research suggests DHEA may improve mood, well-being, and libido in these populations, but results are mixed and often modest.

Despite these findings, the evidence supporting the use of DHEA for general "adrenal support" in otherwise healthy individuals is limited. Most scientific validation comes from studies in people with diagnosed adrenal disorders. Several randomized controlled trials have found modest benefit in quality of life and mood in women with adrenal insufficiency, though effects on physical symptoms and fatigue are inconsistent. Systematic reviews generally conclude that while DHEA supplementation is safe at recommended doses for short-term use, its benefits are limited and not broadly applicable to the general population. In summary, there is scientific evidence for DHEA's role in supporting adrenal function in specific clinical populations, but not for general use as an "adrenal support" supplement.

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