Evidence supporting the use of: DHEA (dehydroepiandrosterone)
For the body system: Adrenal Cortex

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Synopsis

Source of validity: Scientific
Rating (out of 5): 3

DHEA (dehydroepiandrosterone) is an endogenous steroid hormone produced primarily by the adrenal cortex. Its use in supporting adrenal function has a scientific basis, as DHEA is a precursor to androgens and estrogens and plays a role in the body's endocrine system. In individuals with adrenal insufficiency (such as Addison’s disease), DHEA levels are often low, and some studies have examined DHEA supplementation in this context. Research indicates that DHEA supplementation may modestly improve mood, well-being, and some quality of life parameters in people with adrenal insufficiency, particularly in women. However, the effects on fatigue, energy, and overall adrenal function are inconsistent and often modest.

Clinical guidelines do not universally recommend DHEA for adrenal support, as the evidence is mixed and long-term safety data are limited. Outside of frank adrenal insufficiency, the rationale for DHEA supplementation for general "adrenal support" is less clear. While some alternative medicine practices promote DHEA for "adrenal fatigue," this diagnosis is not recognized in conventional medicine, and there is little scientific validation for use in this context.

In summary, DHEA is produced by the adrenal cortex and is sometimes used scientifically in cases of adrenal insufficiency, with moderate evidence for benefits in certain symptoms, but its broader use for general adrenal support is not well substantiated.

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