Evidence supporting the use of: Ginsenosides (unspecified)
For the body system: Adrenal Cortex

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Synopsis

Source of validity: Traditional
Rating (out of 5): 2

Ginsenosides are the primary active compounds in ginseng (Panax species), which have a long history of use in traditional Chinese and Korean medicine. Ginseng has been traditionally employed as an adaptogen—substances believed to help the body resist physical, chemical, or biological stress—often attributed to its effects on the adrenal cortex and stress response. The adrenal cortex produces corticosteroids, including cortisol, which play a key role in the body’s response to stress.

Traditional practices suggest that ginseng and its ginsenosides help to "tonify" the adrenal glands, enhance energy, and improve resilience to stress. However, specific and direct scientific evidence linking ginsenosides to improved adrenal cortex function in humans is limited. Some preclinical studies in animals and isolated cells suggest that ginsenosides may modulate the hypothalamic-pituitary-adrenal (HPA) axis and influence stress hormones, but clinical data in humans are sparse and often inconclusive.

In summary, the use of ginsenosides to support the adrenal cortex system is primarily justified by traditional use, with a modest (2/5) evidence rating due to the lack of robust clinical trials directly confirming efficacy for this purpose in humans.

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