Evidence supporting the use of: Glycyrrhiza (unspecified)
For the body system: Adrenal Cortex

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Synopsis

Source of validity: Traditional
Rating (out of 5): 3

Glycyrrhiza, commonly known as licorice root, has a long history of traditional use in supporting adrenal health and the adrenal cortex. In various systems of traditional medicine, such as Traditional Chinese Medicine (TCM) and Ayurveda, licorice is considered an adaptogen—a substance believed to help the body adapt to stress and support adrenal function. This traditional use stems from observations that licorice root may help with symptoms associated with fatigue and stress, which are often linked to adrenal activity.

Scientifically, licorice contains glycyrrhizin, a compound that inhibits the enzyme 11β-hydroxysteroid dehydrogenase. This enzyme converts active cortisol to inactive cortisone, thereby potentially raising cortisol levels in the body. While this mechanism is well-documented, direct evidence connecting licorice supplementation with improved adrenal cortex function in otherwise healthy individuals is limited. Most modern clinical research focuses on licorice's effects on cortisol metabolism, blood pressure, and its side effects (such as hypokalemia and hypertension), rather than direct adrenal support.

In summary, the use of Glycyrrhiza to "support the adrenal cortex" is justified primarily by tradition, with some plausible biochemical mechanisms but limited direct clinical validation for this specific indication.

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