Rosavin is a key active compound found in the plant Rhodiola rosea, commonly known as golden root or Arctic root. The use of Rhodiola rosea in traditional medicine, particularly in Russia, Scandinavia, and other parts of Eastern Europe, dates back centuries. It has been historically used as an adaptogen, a substance believed to help the body resist physical, chemical, and biological stressors. Traditional healers have employed Rhodiola for improving stamina, reducing fatigue, and promoting resilience during periods of stress—effects thought to be mediated in part through support of the adrenal glands, which are central to the body's stress response via the hypothalamic-pituitary-adrenal (HPA) axis.

Scientific studies have investigated Rhodiola rosea extracts (which contain rosavin), showing some benefits in reducing fatigue and improving cognitive function under stress; however, direct, robust evidence specifically linking rosavin or Rhodiola rosea to measurable support of adrenal cortex function in humans is limited. Most research focuses on general anti-fatigue and adaptogenic effects rather than direct adrenal modulation. Thus, the use of rosavin for adrenal support is primarily justified by a long tradition of use for stress and energy, with some supportive but indirect scientific evidence. The evidence rating is moderate (3/5), reflecting strong traditional use and partial scientific backing, but lacking direct clinical trials targeting adrenal cortex outcomes.