Evidence supporting the use of: Rosavins
For the body system: Adrenal Cortex

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Synopsis

Source of validity: Scientific
Rating (out of 5): 3

Rosavins are a group of phenylpropanoid compounds found in Rhodiola rosea, an adaptogenic herb traditionally used in Russian and Scandinavian medicine. The adrenal cortex is responsible for producing stress hormones such as cortisol. Rhodiola rosea extracts, standardized to contain rosavins, have been studied for their adaptogenic properties, particularly their ability to help the body resist physical, chemical, and biological stressors. Several randomized controlled trials and reviews have reported that Rhodiola rosea supplementation may reduce fatigue, improve mental performance, and modulate cortisol levels in response to stress. These effects are believed to be mediated, at least in part, through action on the hypothalamic-pituitary-adrenal (HPA) axis, which regulates adrenal cortex function.

For example, a 2012 systematic review (Ishaque et al., Phytomedicine) concluded that Rhodiola rosea has a favorable safety profile and shows promise for reducing fatigue and improving stress resilience. However, most studies use the whole extract rather than isolated rosavins, so it is unclear to what extent rosavins alone are responsible for these effects. Nevertheless, the evidence supports the use of rosavin-containing Rhodiola extracts for supporting the body's stress response via adrenal modulation, though more high-quality studies are needed to confirm efficacy and clarify mechanisms.

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