Evidence supporting the use of: Schizandrol A
For the body system: Adrenal Cortex

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Synopsis

Source of validity: Traditional
Rating (out of 5): 2

Schizandrol A is a bioactive compound found in the fruit of Schisandra chinensis, a plant used for centuries in Traditional Chinese Medicine (TCM). In TCM, Schisandra is classified as an adaptogen—a substance believed to help the body resist stressors and support various organ systems, including the adrenal cortex. The adrenal cortex is responsible for producing corticosteroids, hormones involved in stress response, metabolism, and immune function. Schisandra and its constituents, including Schizandrol A, have been traditionally used to combat fatigue, enhance vitality, and improve resilience to stress, which are effects often attributed to adrenal support.

Scientific studies specifically examining Schizandrol A’s effects on the adrenal cortex are limited. Some animal and in vitro research suggests that Schisandra extracts may influence stress hormones and exert adaptogenic effects, but these studies usually involve whole plant extracts rather than isolated Schizandrol A, and direct clinical evidence in humans is lacking. Thus, while traditional use supports its role in supporting the adrenal cortex, robust scientific validation for Schizandrol A’s specific effects on this body system remains insufficient.

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