Evidence supporting the use of: Vitamin C (Ascorbate)
For the body system: Adrenal Cortex

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Synopsis

Source of validity: Scientific
Rating (out of 5): 3

Vitamin C (ascorbate) has scientific backing for its role in supporting the adrenal cortex, though the evidence is moderate. The adrenal glands, particularly the adrenal cortex, have one of the highest concentrations of vitamin C in the body. Research shows that vitamin C is required for steroidogenesis, the process by which the adrenal cortex produces corticosteroids such as cortisol. Animal and in vitro studies have demonstrated that vitamin C acts as a cofactor for enzymes involved in the biosynthesis of adrenal hormones. During physiological stress, the adrenal glands' vitamin C content is rapidly depleted, and supplementation has been shown in some studies to support adrenal function and stress response in both animals and humans. Historical clinical use has included vitamin C as an adjunct for adrenal insufficiency and fatigue, though robust large-scale clinical trials in humans are limited.

Overall, while there is a strong biochemical rationale and supporting preclinical data, high-quality clinical trials specifically demonstrating direct benefits of vitamin C supplementation for adrenal cortex support in humans are lacking. Thus, the evidence is scientifically plausible and supported by mechanism and some clinical observation but does not reach the highest levels of clinical validation.

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