Asparagus racemosus, commonly known as Shatavari, is widely used in Ayurvedic and traditional Indian medicine for its adaptogenic, rejuvenating, and tonic properties. Its traditional use includes supporting the body's ability to cope with stress, enhancing vitality, and nourishing various body systems, which aligns with the concept of "adrenal fatigue" in complementary and alternative medicine. However, "adrenal fatigue" itself is not a formally recognized medical diagnosis, and its existence is debated in mainstream medicine. Historically, Shatavari has been used for conditions thought to be related to stress and exhaustion, which are sometimes interpreted as symptoms of adrenal fatigue in modern holistic health contexts.

Scientific research on Asparagus racemosus mostly centers on its effects as an adaptogen, antioxidant, and immunomodulator. Some animal studies indicate that extracts of Shatavari may help modulate stress responses and reduce markers of stress in rodents, but there is limited clinical evidence in humans, and almost none specifically addressing adrenal function or "adrenal fatigue." The available evidence is insufficient to conclusively validate its use for this purpose, but its traditional reputation as an adaptogen underpins its use in herbal protocols aimed at stress and fatigue.

In summary, the use of Asparagus racemosus for "adrenal fatigue" is primarily justified by traditional medicine, with limited scientific evidence supporting a potential adaptogenic effect. More rigorous human studies are needed to clarify its role, if any, in adrenal or stress-related conditions.