Evidence supporting the use of: Chinese Licorice
For the health condition: Adrenal Fatigue

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Synopsis

Source of validity: Traditional
Rating (out of 5): 2

Chinese Licorice (Glycyrrhiza uralensis) has a long history in Traditional Chinese Medicine (TCM) as an adaptogen and harmonizer, often included in herbal formulas to support the body's response to stress. Its use for "adrenal fatigue" specifically is not rooted in scientific evidence, as "adrenal fatigue" itself is not recognized as a formal medical diagnosis in conventional medicine. However, the concept of supporting energy, reducing fatigue, and modulating stress responses is central to traditional uses. Licorice root contains glycyrrhizin, which can inhibit the breakdown of cortisol, theoretically prolonging its action in the body. In TCM, licorice is considered to "tonify Qi" (vital energy), which practitioners might associate with improved resilience to stress.

On the scientific front, while there are studies indicating licorice’s effects on cortisol metabolism and potential to raise blood pressure, there are no robust clinical trials validating its use for "adrenal fatigue" in humans. Most available data are extrapolated from biochemical knowledge and animal studies or relate to licorice's use in Addison’s disease (adrenal insufficiency), a different and well-defined condition. Thus, licorice’s use for "adrenal fatigue" is justified by tradition and limited biochemical rationale, not by strong scientific validation. Caution is warranted due to possible side effects, such as hypertension and hypokalemia, with chronic or excessive use.

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